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KMID : 1137820150360010016
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의공학회지
2015 Volume.36 No. 1 p.16 ~ p.21
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Development of Indocyanine Green and 5-Aminolevulinic Acid Detection System for Surgical Microscope
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Kim Hong-Rae
Lee Hyun-Min
Yoon Woong-Bae
Kim Young-Jae
Kim Seok-Ki
Yoo Heon
Joo Jae-Young
Kim Kwang-Gi
Lee Seung-Hoon
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Abstract
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Indocyanine green(ICG) and 5-aminolevulinic acid(5-ALA) have been widely used to mark blood vessels or tumors. However, fluorescent dye detection systems were designed to use one type of dyes only. In this study, we proposed a detection system capable of detecting Indocyanine green and 5-aminolevulinic acid. Multiple filters and light sources are integrated into a single system. In this study, we performed analysis of fluorescent dyes and configured a detection system. During the analysis, it was found that Indocyanine green and 5-aminolevulinic acid have the maximum intensity at 40 μM. We designed light source for fluorescent dyes and conducted compatibility test using a commercial surgical microscope. The fluorescent dye detection system was configured based on the experimental results. The developed system successfully detects Indocyanine green and 5-aminolevulinic acid. Therefore, more efficient surgical operations can be achieved using both fluorescent dyes at the same time. We expect that the developed system can increase the survival rate of patients.
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KEYWORD
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Fluorescence Image-Guided Surgery, Brain Glioma, Microscope, Indocyanine Green, 5-Aminolevulinic Acid
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